Bryan is the founder of Sahsen Ventures, which invests in and supports mission-driven enterprises focused on life sciences, education, social justice, and the environment. From 1994 to 2016, he was Co-founder and Chief Investment Officer of Quadra/Quellos and subsequently BlackRock Alternative Advisors.

Bryan also serves or has served on the boards of several startups. He is an advisory board member of the University of Washington Investment Company, the Institute for Protein Design, and the Brotman Baty Institute for Precision Medicine. He earned a BA in Mathematical Economics from Pomona College in 1984 and an MBA degree, with honors, from the University of Chicago in 1989.